Common Drug Names:

Tranq, Tranq Dope

Xylazine, a non-opioid veterinary tranquilizer not approved for human use, has been linked to an increasing number of overdose deaths nationwide in the evolving drug addiction and overdose crisis. Studies show people exposed to xylazine often knowingly or unknowingly used it in combination with other drugs, particularly illicit fentanyl.

The image to the left shows the amount of each drug needed to cause the average person to overdose. Carfentanil, classified as a synthetic opioid and used to tranquilize large animals, is 10,000 times more potent than morphine and 100 times more potent than fentanyl.

Taking opioids in combination with xylazine and other central nervous system depressants—like alcohol or benzodiazepines—increases the risk of life-threatening overdose. People report using xylazine or xylazine-containing drugs by injecting, snorting, swallowing, or inhaling. Xylazine is a central nervous system depressant that can cause;

  • drowsiness
  • amnesia
  • slow breathing and heart rate
  • dangerously low blood pressure
  • skin ulcers
  • abscesses
  • other related complications

At very high doses, or with other central nervous system depressants, xylazine can cause:

  • Loss of physical sensation
  • Loss of consciousness
  • Intensification of the effects of other drugs, which can complicate overdose presentation and treatment.

Overdosing from Xylazine:

Experts recommend giving the opioid overdose reversal medication naloxone because xylazine is frequently combined with opioids. However, because xylazine is not an opioid, naloxone does not address the impact of xylazine on breathing. Because of this, experts are concerned that a growing prevalence of xylazine in the illicit opioid supply may be less effective for some overdoses. Emergency medical services should always be alerted to a suspected overdose.

Withdrawal from xylazine is not a well-defined syndrome due to its "not approved for use in human" nature. However, it is reported to be more intense than opioid withdrawal, and there are far fewer options available to treat it. Symptoms of withdrawal include extreme anxiety that can last for months.

Opioid withdrawal symptoms can be treated with medications like methadone and buprenorphine, but xylazine withdrawal symptoms cannot be treated with these medications.




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Xylazine-involved overdose deaths in Minnesota are relatively low compared to some states, but they are increasing at an alarming rate. The first known xylazine-involved overdose death in Minnesota occurred in 2019. Since then, the number of xylazine-involved deaths has increased every year. In 2019, there were four overdose deaths involving xylazine, followed by eight in 2022 and 24 in 2021. Preliminary 2022 data shows there were 34 xylazine-involved deaths across the state.